Bioinformatician (protein engineering)

• Establishment of bioinformatic methods for predicting mutations in proteins with the aim of improving expression, solubility, stability, and activity.
• Rational protein design, as well as AI-driven predictions to identify and evaluate potential hotspots for directed mutagenesis.
• Utilization of molecular dynamics methods to identify important interaction surfaces using atomistic or coarse-grained simulations.
• Development of internal workflows and toolkits for investigating protein-protein and protein-ligand interactions, e.g. Free energy determination.
• Development of strategies to optimize regulatory elements (e.g. promoter and terminator regions) for targeted control of gene expression in various host organisms.
• Evaluation of data from the fields of genomics, proteomics, and metabolomics to support microbiology groups.
• Evaluation of principles and work with external partners/consultants, provide support for collaboration.
• Proactive knowledge management regarding tools, methods, and best practices.
• Close colaboration with the areas of molecular biology, protein biochemistry, and fermentation.
• Documentation and presentation of results in project meetings.

• M.Sc. or PhD degree in bioinformatics, structural biology, biochemistry, computational biology, or a related field.
• Solid knowledge in the analysis of protein sequences and structures using computational expertise.
• Experience in predicting and evaluating mutations concerning protein structure and function.
• Knowledge in the analysis and optimization of regulatory DNA elements (promoters, terminators).
• Strong skills in Python programming and Linux environments, knowledge of machine learning frameworks (e.g., PyTorch, TensorFlow) are an advantage.
• Experience with cloud computing platforms (preferably Microsoft Azure).
• Experience with Illumina and ONT sequencing data as well as bioinformatics NGS pipelines.
• Team player, self-initiative, and a structured working style.
• Strong problem-solving and analytical skills.
• A passion for continuous learning and improvement.
• Excellent English language skills.

• Competitive Salary (with yearly bonus up to 15%)
• Opportunity for Future Growth and Advancement
• Meal allowance of 123 CZK / day
• Transport allowance of 100 CZK / day
• Vacation allowance 10 000 CZK / year
• Flexi Pass 20 000 CZK / year
• Christmas allowance 10 000 CZK / year
• 5 weeks of holiday and for every 3 years of employment plus 1 extra day of holiday

• Home office option

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